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Objective
To investigate the efficacy of topical 0.2% hyaluronic acid in canine corneal ulcers in vivo.
Procedures
Six purpose‐bred beagles were randomly assigned into two groups (three dogs/group): group A received experimental product (Optimend™, containing 0.2% hyaluronic acid, KineticVet™); group B received control product (Optimend™ without 0.2% hyaluronic acid and supplemented with carboxymethylcellulose)...
Objective
To investigate molecular mechanisms mediating anti‐fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad‐dependent and, to a lesser extent, Smad‐independent signaling pathways activated by TGF‐β1, as well as matrix metalloproteinase (MMP) activity.
Methods
Cultured canine corneal fibroblasts (CCF)...
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