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The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functional link between the ECM proteoglycan Agrin and the transcriptional co-activator...
Cell-based assays can be used prior to in vivo tests to enable quantitative examinations of the responses of cells and, on the tissue scale, tumor-stromal mimics to drugs. However, the challenge is always to reproduce as closely as possible the native-state tumor microenvironment so as to accurately predict in vivo drug responses. In this chapter, we will list the advantages of 3D models over conventional...
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