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Polyketid‐Biosynthese: Die Biosynthese von Aminopolyolen erfolgt durch PKSs. In der Zuschrift auf S. 1766 zeigen I. Abe et al., dass heterologe Expression über 150 kbp großer PKS‐Gencluster neuartige Aminopolyole ergeben kann. Ein phylogenetischer Vergleich von 4 Aminopolyol‐PKS‐Genclustern offenbart den Mechanismus der PKS‐Umprogrammierung.
Polyketides form many clinically valuable compounds. However, manipulation of their biosynthesis remains highly challenging. An understanding of gene cluster evolution provides a rationale for reprogramming of the biosynthetic machinery. Herein, we report characterization of giant modular polyketide synthases (PKSs) responsible for the production of aminopolyol polyketides. Heterologous expression...
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