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Cytosolic phospholipase A2α (cPLA2α) is a rate-limiting key enzyme controlling the release of arachidonic acid (AA) substrate for the synthesis of prostaglandins and leukotrienes. This study was designed to explore the role of hepatocyte cPLA2α in Fas-mediated liver injury, in vivo.Transgenic mice with targeted expression of cPLA2α under control of the albumin-promoter enhancer and wild-type mice...
Deficient biliary epithelial cell (BEC) expression of small proline-rich protein (SPRR) 2A in IL-6 −/− mice is associated with defective biliary barrier function after bile duct ligation. And numerous gene array expression studies show SPRR2A to commonly be among the most highly up-regulated genes in many non-squamous, stressed and remodeling barrier epithelia. Since the function of SPRR in...
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