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A protocol applicable for the synthesis of an oseltamivir positron emission tomography (PET) tracer was developed. Acetylation of amine 3 with CH 3 COCl, followed by deprotection and aqueous workup, produced oseltamivir 4 from 3 within 10min. The obtained 4 was sufficiently pure for PET studies. This method can be extended to PET tracer synthesis using CH 311 COCl.
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