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We have recently described that integrin αvβ3 upon interaction with its major extracellular matrix ligand vitronectin induces adhesion, motility, and proliferation of human ovarian cancer cells. Due to the important function of αvβ3 in cancer cell biology, it has been the effort of many scientific approaches to specifically target αvβ3-mediated cell adhesion and tumorbiological effects arising thereof...
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