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The use of noncanonical amino acids (ncAAs) to control the viability of an organism provides a strategy for the development of conditional “kill switches” for live vaccines or engineered human cells. We report an approach inspired by the posttranslational acetylation/deacetylation of lysine residues, in which a protein encoded by a gene with an in‐frame nonsense codon at an essential lysine can be...
Eine neue posttranslational modifizierte Aminosäure, Crotonyllysin (Kcr), wurde mithilfe eines evolvierten Pyrrolysyl‐tRNA/Synthetase‐tRNA‐Paares gentechnisch in Proteine in Bakterien‐ und Säugerzellen eingebaut. Die Fähigkeit, Histone mit homogenen ortsspezifischen KCr‐Modifikationen herzustellen, wird helfen, die biologische Rolle dieser kürzlich identifizierten posttranslationalen Modifikation...
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