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While single‐molecule sensing offers the ultimate detection limit, its throughput is often restricted as sensing events are carried out one at a time in most cases. 2D and 3D DNA origami nanostructures are used as expanded single‐molecule platforms in a new mechanochemical sensing strategy. As a proof of concept, six sensing probes are incorporated in a 7‐tile DNA origami nanoassembly, wherein binding...
DNA‐Origami‐Nanokacheln wurden als neuartige mechanochemische Mehrfachsensoren eingeführt. In ihrer Zuschrift auf S. 8275 ff. zeigen M. Endo, H. Sugiyama, H. Mao et al., dass durch das Binden spezifischer Zielmoleküle an den Sensor die miteinander verbundenen Kacheln entsperrt werden und sich die räumliche Struktur der DNA‐Nanostruktur neu anordnet. Dieser Prozess wurde in Echtzeit mithilfe einer...
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