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Rat liver 3α-hydroxysteroid dehydrogenase (3α-HSD or AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, plays a pivotal role in the inactivation of circulating steroid hormones. It is the most thoroughly characterized HSD of the AKR superfamily and can be used as a template for structure-function studies in other AKR members such as rodent and human 3α-, 17β- and 20α-HSDs. Based on the...
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