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The self‐assembled nanoparticles for siRNA delivery with lipid‐modified aminoglycoside derivatives is described by Daniel G. Anderson and co‐workers on page 4641. The core‐shell nanoparticles can protect siRNA from enzymatic degradation within the body and subsequently deliver siRNA into cytoplasm of target cells. The image is courtesy of Dr. Ning Zhang.
Rationally designed siRNA delivery materials that are enabled by lipid‐modified aminoglycosides are demonstrated. Leading materials identified are able to self‐assemble with siRNA into well‐defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two...
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