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We used fluorescence resonance energy transfer previously to show that the interferon-γ (IFN-γ) receptor complex is a preformed entity mediated by constitutive interactions between the IFN-γR2 and IFN-γR1 chains, and that this preassembled entity changes its structure after the treatment of cells with IFN-γ. We applied this technique to determine the structure of the interleukin-10 (IL-10) receptor...
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