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A series of ω-substituted fatty acids with potential heme-coordinating groups was synthesized as inhibitors of lauric acid ω-hydroxylation. The compounds were evaluated using liver microsomes from clofibrate (CF)-induced rats and an engineered expressed CYP4A1-derived fusion protein called f4A1. ω-Imidazolyl-decanoic acid (compound 11) and ω-aminolauric acid (compound 7) were potent Type II ligands...
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