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Thimet oligopeptidase (TOP) is a thiol- andmetallo-dependent peptidase and has been shown to beone of the β-secretase candidates. TOPexpressed in COS cells cleaved amyloid precursorprotein (APP) at the β-secretase site, and wefound a proteolytic product of APP called secretedform of APP by β-secretase (sAPPβ) in theconditioned media. Here we demonstrate thatsAPPβ was increased in conditioned media...
A large soluble N-terminal fragment of Alzheimer's disease amyloid precursor protein (secreted form of APP: APP s ) is produced by constitutive processing in the middle of the amyloid β-protein portion of APP. Recent studies indicate that the activation of endogenous protein kinase C (PKC) with phorbol ester raises the rate of secretion of APP s . We constructed rat fibroblast 3Y1...
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