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Though additive forms of heritability are primarily studied in genetics, nonlinear, non‐additive gene–gene interactions, that is, epistasis, could explain a portion of the missing heritability in complex human diseases including cancer. In recent years, powerful computational methods have been introduced to understand multivariable genetic factors of these complex human diseases in extremely high‐dimensional...
Background The PIK3CAH1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CAH1047R mutation in high effectiveness. Methods A 126-bp fragment of PIK3CA exon-20 was amplified by PCR, digested with FspI restriction...
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