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In this study we describe a low-cost and reliable method for inducing fever in young male rats (28–30 days of age, 75–90g), which seems suitable for the screening of new antipyretics. The effects of temperature measuring procedure-induced stress on the basal rectal temperature and on Baker yeast-induced hyperthermia was assessed. Rectal temperature (T R ) was recorded every hour for 12h (07:00–19:00h)...
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