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Long‐term high‐fat diet (HFD) will lead to obesity and their complications. Echinocystic acid (EA), a triterpene, shows anti‐inflammatory and antioxidant effects. We predict that EA supplementation can prevent obesity, diabetes, and nonalcoholic steatohepatitis. To test our hypothesis, we investigated the effects of EA supplementation on mice with HFD‐induced obesity in vivo and in vitro by adding...