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α‐Lipoic acid, known for its anti‐inflammatory and antioxidant activity, represents a promising ligand for Pt(IV) prodrugs. Three new Pt(IV) lipoate complexes were synthesized and characterized by NMR spectroscopy (1H, 13C, 195Pt), mass spectrometry and elemental analysis. Due to the low solubility of the complex containing two axial lipoate ligands, further experiments to examine the biological activity...
Front Cover. To overcome the limitations of Pt(II) drugs for cancer treatment (intrinsic or acquired resistance, severe side‐effects), the investigations on Pt(IV) complexes and their anticancer activity provide a promising strategy. Beside higher kinetic inertness and lower toxicity compared to Pt(II), Pt(IV) complexes are armed with two axial ligands for further modification of their pharmacological...
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