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The popular short echo time 1H MR spectroscopy acquisition method for detection of intramyocellular lipids suffers from spectral overlap due to the large, broad, and asymmetric extramyocellular lipid signals, the time‐consuming practice of selecting “lean” voxels for spectroscopy, and the overlap of the extramyocellular lipid signal with the creatine methyl 1H signal at ∼3 parts per million (ppm),...
Triglyceride turnover in the isolated C57/BL6 mouse heart was measured by dynamic 13 C edit- 1 H observe NMR and the rate of fatty acid oxidation was determined by 13 C NMR isotopomer analysis. In the presence of a physiological mixture of substrates, energy was produced in the citric acid cycle by oxidation of long-chain fatty acids (18%), ketones (34%), lactate (24%), pyruvate...
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