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β‐Faltblätter sind wichtige Sekundärstrukturelemente gefalteter Proteine und häufig an therapeutisch bedeutsamen Protein‐Protein‐Wechselwirkungsflächen anzutreffen, so auch in Amyloid‐Ablagerungen bei vielen neurodegenerativen Erkrankungen. In ihrer Zuschrift auf S. 3724 ff. schildern A. D. Hamilton, S. Thompson et al. eine Strategie für die Modulierung dieser Wechselwirkungen: Mithilfe eines tetrasubstituierten...
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display β‐sheet structures in two directions. Extensive X‐ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic...
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