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Choline dihydrogen phosphate (CDHP) is a low melting point organic salt reported to increase the thermal stability of model proteins. The purpose of the current work was to investigate the effect of CDHP on recombinant human interleukin-2 (rhIL-2) functional and structural integrity, a therapeutic protein used for treating advanced melanoma. Structural integrity and biological activity of rhIL-2 formulated...
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