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The purpose of this research was to develop a rapid chemometrical method based on near-infrared (NIR) spectroscopy to determine indomethacin (IMC) polymorphic content in mixed pharmaceutical powder and tablets. Mixed powder samples with known polymorphic contents of forms α and γ were obtained from physical mixing of 50% of IMC standard polymorphic sample and 50% of excipient mixed powder sample consisting...
The relationship between in vitro and in vivo drug release from a self-setting bioactive calcium phosphate cement containing indomethacin (IMC) as a model drug was investigated. The in vitro IMC release rate from 1, 2 and 5% drug-loaded cement systems in simulated body fluid (SBF) at pH 7.25, 37 o C increased with increase of drug concentration in the cement. The decreasing amount of calcium...
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