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Michael addition of lithiated chiral aminonitriles 1a,b to α,β-unsaturated lactone 2 afforded (4R)-aroyl-δ-lactones 8a,b with a ee value ≥ 99%. Michael addition / subsequent α alkylation process gave the corresponding (3S)-substituted-(4R)-aroyl-δ-lactones 9-10a, 9b with a ee value of 66 up to 87% and 11-12a with high enantiomeric purity the ee being \> 99%. The absolute configuration of the...
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