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We have recently found that the computation time of homology-based subcellular localization can be substantially reduced by aligning profiles up to the cleavage site positions of signal peptides, mitochondrial targeting peptides, and chloro-plast transit peptides [1]. While the method can reduce the profile alignment time by as much as 20 folds, it cannot reduce the computation time spent on creating...
The functions of proteins are closely related to their subcellular locations. In the post-proteomics era, the amount of gene and protein data grows exponentially, which necessitates the prediction of subcellular localization by computational means. This paper proposes mitigating the computation burden of alignment-based approaches to subcellular localization prediction by using the information provided...
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