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A selective monodefluorinative alkylation of 3,3‐difluorooxindoles is achieved. The reaction starts by the attack of a 4‐dimethylaminopyrine‐boryl radical to the carbonyl oxygen atom of 3,3‐difluorooxindoles, followed by a spin‐center shift to generate radical intermediates with the elimination of a fluoride anion. The subsequent radical addition to alkenes affords a range of 3‐alkyl‐fluorooxindoles...
Chiral‐at‐metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R‐modafinil acid and its analogues with high yields and ee values. The efficient resolution process was achieved based on the diastereoselective discrimination caused by hydrogen bond and intramolecular π‐π interaction between chiral‐at‐metal center and the coordinated chiral sulfoxide ligands. Moreover,...
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