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BACKGROUND: Asthma is characterized by an accumulation of activated eosinophils in the airway. Eosinophil viability–enhancing activity is present in the sputum of patients with asthma, largely because of granulocyte-macrophage colony-stimulating factor (GM-CSF). Bronchial epithelial cells have been shown to release cytokines including GM-CSF when stimulated with IL-1β or tumor necrosis factor-α. OBJECTIVE:...
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