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ObjectiveDuring the course of rheumatoid arthritis (RA), fibroblast‐like synoviocytes (FLS) are chronically exposed to an inflammatory milieu. The purpose of this study was to test the hypothesis that prolonged exposure of FLS to tumor necrosis factor α (TNFα) augments inflammatory responses to secondary stimuli (priming effect).
MethodsFLS obtained from RA patients were exposed to TNFα for 3 days...
ObjectiveThe nonresolving character of synovial inflammation in rheumatoid arthritis (RA) is a conundrum. To identify the contribution of fibroblast‐like synoviocytes (FLS) to the perpetuation of synovitis, we investigated the molecular mechanisms that govern the tumor necrosis factor α (TNFα)–driven inflammatory program in human FLS.
MethodsFLS obtained from the synovial tissues of patients with...
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