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The study was performed to clarify the effects of active vitamin D (alfacalcidol) and/or alendronate (ALN) on bone tissue turnover in glucocorticoid (GC)-treated growing minipigs. Göttingen minipigs aged 8 months were divided into six groups (n = 5 each): group BC, killed for baseline control; group GC, injected subcutaneously with prednisolone (0.5 mg/kg body weight [BW] per day, 5 days/week for...
To clarify the effects of 1 alpha,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) on bone growth, strength, and turnover in growing rats with liver cirrhosis induced by carbon tetrachloride (CCl 4 ) injection, groups of 4-week-old male Wistar rats (n = 10, each) were injected intraperitoneally with CCl 4 twice weekly for 7 weeks. One group was treated with the vehicle...
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