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Cyclooxygenase inhibitors decrease micturition frequency in animals with bladder inflammation but to our knowledge the influence of cyclooxygenase inhibitors on detrusor overactivity has not been investigated. We evaluated the effects, and the site and mechanism of action of cyclooxygenase inhibitors on detrusor overactivity induced by cerebral infarction.Cerebral infarcted rats underwent cumulative...
α 1 -Blockers improve voiding symptoms by decreasing prostatic and urethral smooth muscle tone. However, to our knowledge the mechanism underlying improvements in storage symptoms is not known. Topical application of prostaglandin E 2 to the rat lower urinary tract stimulates the micturition reflex. Using an animal model we investigated whether the α 1 -blocker tamsulosin (Astellas...
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