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Background
The aim of this study was to investigate the prevalence of epidemiologic and physician‐diagnosed pollen‐induced AR (PiAR) in the grasslands of northern China and to study the impact of the intensity and time of pollen exposure on PiAR prevalence.
Methods
A multistage, clustered and proportionately stratified random sampling with a field interviewer‐administered survey study was performed...
Background
The overproduction of IgE plays a critical role in the pathogenesis of allergy; the mechanism is unclear. Histone‐acetyltransferase (HAT) activities are required in gene transcription of a large number of molecules in the immune system of the body.
Objectives
This study tests a hypothesis that HAT Tat‐interactive protein 60 (Tip60) plays an important role in the initiation of IgE‐mediated...
Background and Aims
Mast cell activation interferes with the effects of allergen‐specific immunotherapy (SIT). Galectin‐1 (Gal‐1) is capable of regulating immune cells’ functions. This study tests the hypothesis that administration of Gal‐1 promotes and prolongs the efficacy of SIT via suppressing mast cell activation.
Methods
An intestinal allergy mouse model was developed. The coadministration...
Background
Asthma is an allergic airway disease (AAD) caused by aberrant immune responses to allergens. Protein phosphatase‐2A (PP2A) is an abundant serine/threonine phosphatase with anti‐inflammatory activity. The ubiquitin proteasome system (UPS) controls many cellular processes, including the initiation of inflammatory responses by protein degradation. We assessed whether enhancing PP2A activity...
Background and aims
The function of interleukin (IL)‐10‐producing B cells (B10 cell) is compromised in patients with allergic diseases. Protease‐activated receptor (PAR)‐2 has immunoregulatory functions. This study aimed to elucidate the role of PAR2 in the suppression of IL‐10 expression in peripheral B cells.
Methods
Peripheral blood B cells were collected from patients with allergic rhinitis...
Background and aims
Mast cells are the major effector cells in allergic disorders and many other informatory disorders. The mechanism of mast cell stabilization is not fully understood. Cumulative reports indicate that vitamin D (VitD) contributes to the homeostasis in the body. This study tests a hypothesis that VitD is required in the maintenance of the stability of mast cells.
Methods
The stability...
Background
The generation of the tolerogenic dendritic cells (DC) is not fully understood yet. Forkhead box protein‐3 (Foxp3) is an important molecule in the immune tolerance. This study tests a hypothesis that DCs express Foxp3, which can be upregulated by Staphylococcal enterotoxin B (SEB).
Methods
The expression of Foxp3 by DCs was evaluated by real‐time RT‐PCR, Western blotting, flow cytometry,...
BackgroundAllergic Rhinitis Control Test (ARCT) has been validated for assessing allergic rhinitis (AR) control and identifying severe AR. The aim of the study was to assess the ARCT questionnaire as a tool for stepwise pharmacotherapy.
MethodsA standard pharmacotherapy regimen from Step 1 (oral second‐generation H1 antihistamine as needed) to Step 5 (oral corticosteroid) was carried out prospectively...
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