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Premature ejaculation (PE), despite its wide prevalence, is largely underdiagnosed and undertreated. Being a multifactorial dysfunction with strong cultural characteristics, PE requires skillful attitudes in the psychosexological support, necessary to manage the patient's and the couple's expectations, as well as in the medical treatment. Dapoxetine is a short‐acting selective serotonin reuptake...
Background
Recently, dapoxetine has been widely accepted to treat premature ejaculation by fast‐inhibiting 5‐hydroxytryptamine reuptake. However, dapoxetine is not suitable for all premature ejaculation patients in clinical treatment. We need to investigate and reveal the mechanism deeply to solve this problem.
Objectives
To investigate and reveal the function of dopamine D4 receptor in dapoxetine...
The primary goal of this systematic review and meta‐analysis was to compare the efficacy and safety of fluoxetine with other oral pharmaceuticals in the treatment of premature ejaculation (PE). We searched through databases including CNKI, PubMed, EMBASE and Cochrane to find research published up to 31 March 2022. PROSPERO was used to pre‐register this meta‐analysis (registration number CRD42022315459)...
Background
Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase‐2 (TPH2) is considered to be the key enzyme for the synthesis of 5‐hydroxytryptamine (5‐HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation.
Objectives
This study aimed to investigate...
This study was to explore whether serotonin transporter gene‐linked polymorphic region polymorphisms (5‐HTTLPR+rs25531) influence the response to dapoxetine treatment in a Chinese population with premature ejaculation (PE). 112 patients with PE re‐enrolled from our previous study received dapoxetine monotherapy. At the endpoint, patients with S’S’ had a significant increased risk of nonresponse compared...
Limited evidence has indicated that brain‐derived neurotrophic factor (BDNF) may be involved in the neurobiology of premature ejaculation (PE). This study aimed to investigate BDNF levels in the central and peripheral nervous systems of a rapid ejaculation model. Eighteen male rats were selected and classified as ‘sluggish’, ‘normal’ and ‘rapid’ ejaculators on the basis of ejaculation frequency during...
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