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Radioligand binding studies revealed that Ang IV binds to insulin‐regulated aminopeptidase (IRAP)/’AT4 receptors’ with high affinity. Yet, as these experiments were routinely carried out in the presence of chelators, only the catalytic zinc‐depleted apo‐form of IRAP was labelled. While the chelators remove the catalytic zinc from IRAP and protect Ang IV from proteolytic degradation, the aminopeptidase...
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