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Attention deficit hyperactivity disorder is a chronic neurodevelopmental disorder, manifesting primarily as attention deficit, hyperactivity and impulsive behaviour. General anaesthetics can be neurotoxic, affecting neuronal differentiation and synaptogenesis, which can lead to abnormalities of cognition, learning and behaviour. We hypothesise that exposure of the immature brain to general anaesthetics...
We randomly allocated 80 patients to intravenous dexmedetomidine (0.25, 0.5, or 1 μg.kg−1) or placebo 15 min before anaesthetic induction. Dexmedetomidine 0.5 and 1.0 μg.kg−1 significantly reduced the mean (95% CI) propofol effect‐site concentrations by 0.83 (0.63–1.03) μg.ml−1, p = 0.001 and 1.29 (1.12–1.46) μg.ml−1, p = 0.0003 at intubation, by 1.05 (0.85–1.25 μg.ml−1, p = 0.0006 and 1.33 (1.15–1...
We compared the minimum local analgesia concentration of ropivacaine for intra‐operative caudal analgesia in pre‐school and school age children. Fifty‐one boys, undergoing hypospadius repair surgery, were stratified into pre‐school or school age groups. After induction of anaesthesia, caudal block was performed with ropivacaine 1 ml.kg−1 of the desired concentration. The first child in each group...
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