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Successfully forming ligand–protein complexes with specific compounds can be a significant challenge in supporting structure‐based drug design for a given protein target. In this respect, an on‐column ligand‐ and detergent‐exchange method was developed to obtain ligand–protein complexes of an adamantane series of compounds with 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) after a variety of...
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