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Influenza A viruses (H3N2) isolated in MDCK cells after 1992/1993 influenza season have changed in that these viruses agglutinate human red blood cells (HRBC) but not chicken RBC (CRBC) (Ch- virus). The yield of Ch- virus in MDCK cells was comparable with that of the virus that could agglutinate CRBC (Ch+ virus); however, binding assays revealed reduced binding of the Ch- virus to MDCK cells. Replacement...
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