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3‐epi‐1α,25‐dihydroxyvitamin D3 (3‐epi‐1α,25(OH)2D3), a natural metabolite of 1α,25‐dihydroxyvitamin D3 (1α,25(OH)2D3), exhibits potent vitamin D receptor (VDR)‐mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion. These VDR‐mediated actions of 3‐epi‐1α,25(OH)2D3 needed an explanation as 3‐epi‐1α,25(OH)2D3, unlike 1α,25(OH)2D3, exhibits low affinity...
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