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Type III interferons (IFN-λs) signal through a heterodimeric receptor complex composed of the IFN-λR1 subunit, specific for IFN-λs, and interleukin-10Rβ (IL-10Rβ), which is shared by multiple cytokines in the IL-10 superfamily. Low affinity of IL-10Rβ for cytokines has impeded efforts aimed at crystallizing cytokine-receptor complexes. We used yeast surface display to engineer a higher-affinity IFN-λ...
Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P 2 ) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P 2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the...
Background: Several studies have demonstrated techniques in differentiating human adipose‐derived stem cells (hADSCs) into hepatocytes. Unfortunately, transdifferentiation is inefficient, and the function of these induced hepatocyte‐like cells (which we termed ‘iHeps’) is low compared with that of real hepatocytes.
Aims: We aimed to identify transcriptional deficiencies in iHeps that are critical...
Introduction: Hepatocyte cellular transplantation, a potential alternative to liver transplantation, has been successfully applied in animal models and in clinical studies as a ''bridge'' to transplantation. This approach is challenged by limited donor hepatocytes and by the inability to maintain the long-term survival and expansion of hepatocytes in vitro. We propose that the in vitro expansion and...
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