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A novel bioinspired strategy for protein nanoparticle (NP) synthesis to achieve pH‐responsive drug release exploits the pH‐dependent changes in the coordination stoichiometry of iron(III)–3,4‐dihydroxyphenylalanine (DOPA) complexes, which play a major cross‐linking role in mussel byssal threads. Doxorubicin‐loaded polymeric NPs that are based on FeIII–DOPA complexation were thus synthesized with a...
Muschel‐inspirierte Protein‐Nanopartikel werden von H. J. Chan et al. in ihrer Zuschrift auf S. 7426 ff. vorgestellt. Sie zeichnen sich durch eine pH‐regulierbare Wirkstofffreisetzung aus, die auf pH‐abhängigen Stöchiometrieänderungen von Eisen(III)‐DOPA‐Komplexen basiert, und könnten zum kontrollierten Wirkstofftransport verwendet werden (DOPA=3,4‐Dihydroxyphenylalanin).
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