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Adhäsivproteine Muschelklebstoff mit einem sehr hohen Dopa‐Gehalt wurde durch aminosäurespezifischen Dopa‐Einbau in Escherichia coli erzeugt, wie H. J. Cha et al. in der Zuschrift auf S. 13578 ff. beschreiben. Der Bioklebstoff ist stark adhäsiv und wasserfest.
Misaminoacylation of 3,4‐dihydroxyphenylalanine (Dopa) molecules to tRNATyr by endogenous tyrosyl‐tRNA synthetase allowed the quantitative replacement of tyrosine residues with a yield of over 90 % by an in vivo residue‐specific incorporation strategy, to create, for the first time, engineered mussel adhesive proteins (MAPs) in Escherichia coli with a very high Dopa content, close to that of natural...
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