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In an attempt to increase the specific TPO productivity (qTPO) of rCHO cells (CHO-TPO), the effect of expression level of calnexin (CNX) and calreticulin (CRT) on qTPO was investigated. To regulate the CNX and CRT expression level simultaneously, the Tet-Off system was first introduced in CHO-TPO cells and stable Tet-Off cells (TPO-Tet-Off) were screened by the luciferase assay...
To better understand intracellular responses rCHO cells expressing an antibody to hyperosmotic pressure, we have taken a proteomics approach. Using two-dimensional electrophoresis and mass spectrometry, a proteome profile of rCHO cells comprising 23 identified proteins was established. Based on this proteome profile, we found 3 proteins of which expression levels were significantly changed at 450...
Programmed cell death (apoptosis and autophagy) in cell cultures is considered an important problem to be dealt with as it affects the viable cell concentration and the product quality. This chapter describes various strategies employed to confront and prevent programmed cell death in biotechnologically important mammalian cell lines, mainly Chinese Hamster Ovary (CHO) cells, with special importance...
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