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Transport models are developed for the adsorption of monoclonal antibody charge variants in cation exchange columns for two different matrices: UNOsphere S, which has a macroporous architecture, and Capto S, which contains charged dextran polymers grafted to an agarose matrix. The UNOsphere S protein adsorption kinetics is described by a macropore diffusion model with effective pore diffusivity De...
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