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Phospholipid vesicles encapsulating Hb (Hb-vesicles: HbV) have been developed for use as artificial O 2 carriers (250nmφ). As one of the safety evaluations, we analyzed the influence of HbV on the organ functions by laboratory tests of plasma on a total of 29 analytes. The HbV suspension ([Hb]=10g/dl) was intravenously infused into male Wistar rats (20ml/kg; whole blood = 56ml/kg). The blood...
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