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Prostate cancer (PCa) with prostate‐specific membrane antigen (PSMA)‐specific high expression is well suited for molecularly targeted theranostics. PSMA expression correlates with the malignancy of PCa, and its dimeric form can promote tumor progression by exerting enzymatic activity to activate downstream signal transduction. However, almost no studies have shown that arresting the procancer signaling...
In article number 2005449, Qiyun Tang, Yang Shi, Dan Ding, and co‐workers report a simple short alkyl modified strategy to regulate the molecular aggregation state and remarkably improve the luminescent efficiency and phosphorescence lifetime of pure organic room temperature phosphorescence (RTP) materials. The crystalline nanoparticles of RTP molecules are prepared with a “Top‐Down” method, which...
Pure organic persistent room temperature phosphorescence (RTP) materials have attracted wide attention owing to their great potential in various applications, particularly in bioimaging. However, it is still a challenge to manufacture organic RTP materials possessing quite high efficiency and long lifetime, owing to the high requirements for triplet excitons. In this study, a series of keto derivatives...
Aggregation induced emission (AIE) has attracted considerable interest for the development of fluorescence probes. However, controlling the bioconjugation and cellular labeling of AIE dots is a challenging problem. Here, this study reports a general approach for preparing small and bioconjugated AIE dots for specific labeling of cellular targets. The strategy is based on the synthesis of oxetane‐substituted...
2D materials (TDMs) have been explored for photonic theranostics. To achieve deep‐tissue penetration, near‐infrared (NIR) light is essential for photoacoustic (PA) theranostics. However, because the absorption profiles of existing TDMs are generally featureless with no obvious NIR absorption peaks, their PA signals and therapeutic efficacies are limited. This paper herein reports the synthesis and...
A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9‐bis(2‐(2‐(2‐methoxyethoxy)ethoxy)‐ethyl)fluorenyldivinylene]‐alt‐4,7‐(2,1,3‐benzothiadiazole) with bright red emission...
Multifunctional conjugated polymer nanoparticles (CPNs) are developed for image‐guided phototherapy by D. Ding, B. Liu, and co‐workers in article number 1602807. Under proper light irradiation, these CPNs display bright red fluorescence, efficient singlet oxygen generation and excellent photothermal conversion abilities. With affibody decoration, these CPNs show excellent tumor targeting and synergistic...
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