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Background
With the popularity of serum prostate‐specific antigen (PSA) screening, the number of newly diagnosed prostate cancer (PCa) patients is increasing. However, indolent and invasive PCa cannot be distinguished by the PSA level. Here, we mainly explored the role of heterogeneous nuclear ribonucleoprotein M (hnRNPM) in the invasiveness of PCa.
Methods
Reverse‐transcription quantitative polymerase...
BACKGROUNDCalcium‐mediated proteolysis plays an important role in cell migration. Lysophosphatidic acid (LPA), a lipid mediator present in serum, enhances migration of carcinoma cells. The effects of LPA on calpain‐mediated proteolysis were, therefore, examined in PC‐3, a human prostate cancer cell line.
METHODSCultured PC‐3 cells were used in studies utilizing pharmacologic interventions, immunoblotting,...
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