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In this review, we examine the so‐called OB‐fold, a tRNA‐binding domain homologous to the bacterial tRNA‐binding protein Trbp111. We highlight the ability of OB‐fold homologs to bind tRNA species and summarize their distribution in evolution. Nature has capitalized on the advantageous effects acquired when an OB‐fold domain binds to tRNA by evolutionarily selecting this domain for fusion to different...
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