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Lipofuscin, an aging marker in the retinal pigment epithelium (RPE) associated with the development of age‐related macular degeneration, is primarily characterized by its fluorescence. The most abundant component of RPE lipofuscin is N‐retinylidene‐N‐retinylethanolamine (A2E) but its exact composition is not known due to the complexity of the RPE extract. In this study, we utilized MALDI imaging to...
The accumulation of lipofuscin in the retinal pigment epithelium (RPE) has been implicated in the development of age-related macular degeneration (AMD) in humans. The exact composition of lipofuscin is not known but its best characterized component is N-retinylidene-N-retinylethanolamine (A2E), a byproduct of the retinoid visual cycle. Utilizing our recently developed matrix-assisted laser desorption/ionization...
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