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The cyclophilin of Bacillus subtilis has a moderate affinity to cyclosporin A (IC 50 : 120 nM) and low catalytic activity (k cat /K m : 1.1 μM -1 s -1 ) when compared to other ubiquitous peptidyl-prolyl cis-trans isomerases (PPIases). The active site residues V52, H90 and H109, which are not conserved within other peptidyl-prolyl cis-trans...
Cyclophylins are members of a class of proteins with peptidyl-protyl cis-trans isomerase activity. These enzymes bind the immunosuppressive agent, cyclosporin A (CsA), which acts as a competitive inhibitor. The peptidyl-prolyl cis-trans isomerase from Bacillus subtilis (PPlase) was purified to homogeneity in a 4-step purification procedure, which resulted in a 100-fold protein purification with a...
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