The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Photoaffinitätssonden wurden gezielt darauf entwickelt, cyclinabhängige Kinasen (CDKs) anzusteuern, die als Zeitnehmer zellulärer Prozesse angesehen werden können. Wie J. T. Bush und Mitarbeiter in ihrem Forschungsartikel auf S. 17483 berichten, reichern diese Sonden CDKs aus Zelllysaten kompetitiv an. Ein biochemischer Photoaffinitätsverdrängungstest wurde zur Messung der Wirkstoffpotenz entwickelt...
The CDK family plays a crucial role in the control of the cell cycle. Dysregulation and mutation of the CDKs has been implicated in cancer and the CDKs have been investigated extensively as potential therapeutic targets. Selective inhibition of specific isoforms of the CDKs is crucial to achieve therapeutic effect while minimising toxicity. We present a group of photoaffinity probes designed to bind...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.