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Low responsiveness to anti‐programmed death‐1/programmed death‐ligand 1 (anti‐PD‐1/PD‐L1) for solid tumors indicates the presence of other immunosuppressive pathways. Siglec15, a newly discovered immune checkpoint, has been reported to repress immune responses in the tumor microenvironment (TME) and regulate osteoclast differentiation. However, the role of Siglec15 in the treatment for bone metastasis...
Atherosclerosis Treatment
Herb derived drugs modulate gut microbiome homeostasis and gut‐generated bio‐metabolites. In article number 2105021, Jian‐Dong Jiang, Yongsheng Che, Lu‐Lu Wang, and co‐workers modify the immune cell dynamics and liver function using herb‐derived bicyclol, leading to improved chronic inflammation and cholesterol metabolism. The endothelial activation and cholesterol ester...
Atherosclerosis (AS) is associated with high morbidity and mortality, thus imposing a growing burden on modern society. Herb‐derived bicyclol (BIC) is a versatile bioactive compound that can be used to treat AS. However, its efficacy in AS is not yet described. Here, it is shown that BIC normalizes gut microflora dysbiosis induced by a high fat diet in Apoe(−/−) mice. Metagenome‐wide association study...
For multiplex and ultrasensitive quantification of inflammatory biomarkers in point‐of‐care testing (POCT) scenarios, Xiangwei Zhao and co‐workers introduce anodic aluminum oxide (AAO) with an ordered nanofluidic channel array into vertical flow assays in combination with SERS nanotags in article number 2002801, which results in amplified signals, improved immunoreaction kinetics and detection repeatability...
There is a great demand for the development of detection assays for inflammation infection diagnosis with high throughput and ultrasensitivity. Herein, a vertical flow assay system with functionalized nanoporous anodic aluminum oxide (AAO) as sensing membrane, and encoded core–shell surface enhanced Raman scattering (SERS) nanotags as labels for multiple inflammatory biomarkers detection is presented...
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