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The contact lens (CL) industry has made great strides in improving CL‐wearing experiences. However, a large amount of CL wearers continue to experience ocular dryness, known as contact lens‐induced dry eye (CLIDE), stemming from the reduction in tear volume, tear film instability, increased tear osmolarity followed by inflammation and resulting in ocular discomfort and visual disturbances. In this...
Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with the goal of providing more human‐like models for biopharmaceutical research. In this study, the first such model of the blood‐brain barrier (BBB‐on‐chip) featuring both isogenic human induced pluripotent stem cell (hiPSC)‐derived cells and continuous barrier integrity monitoring with <2 min temporal resolution...
Microphysiological Systems
In article number 2101785, Thomas E. Winkler, Anna Herland, and co‐authors describe a microphysiological blood‐brain barrier model that captures the multicellular interactions of iPS‐derived cells. The integrated electrical sensors, facilitated by PDMS‐free fabrication, allow for real‐time monitoring of how the barrier responds to oxidative stress and antioxidant prophylaxis...
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