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Previous studies have indicated that thalamic nucleus submedius (Sm) is involved in nociceptive modulation and plays an important role in an endogenous analgesic system (a feedback loop) consisting of spinal cord (Sc)–Sm-ventrolateral orbital cortex–periaqueductal gray–Sc. However, the function of different types of Sm neurons in nociceptive modulation is unclear. For this reason, on the basis of...
Our previous studies have indicated that the thalamic nucleus submedius (Sm) is involved in nociceptive modulation and plays an important role in an endogenous analgesic system (a feedback loop) consisting of spinal cord – Sm – ventrolateral orbital cortex (VLO) – periaqueductal gray (PAG) – spinal cord. To further investigate the neurotransmitter and receptor mechanisms in this nociceptive modulatory...
This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing stimulation intensity. Stimulation in the dorsal part of Sm did not produce any...
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